dc.contributor.author |
Sirikhansaeng, Prapaparn |
|
dc.contributor.author |
Tanee, Tawatchai |
|
dc.contributor.author |
Sudmoon, Runglawan |
|
dc.contributor.author |
Chaveerach, Arunrat |
|
dc.date.accessioned |
2019-06-15T08:07:57Z |
|
dc.date.available |
2019-06-15T08:07:57Z |
|
dc.date.issued |
2017-01-16 |
|
dc.identifier.uri |
http://dspace.bru.ac.th/xmlui/handle/123456789/4731 |
|
dc.description.abstract |
Medicinal plants in genus Lagerstroemia were investigated for phytochemical contents by GC-MS and HPLC with ethanol and hexane extracts and their toxicity MTT and comet assay on human peripheral blood mononuclear cells (PBMCs). γ-Sitosterol is the major component found in all species at 14.70–34.44%. All of the extracts, except for L. speciosa ethanol extract, showed high percentages of cell viability. The IC50 value, 0.24 mg/mL, of ethanol L. speciosa extract predicted an LD50 of 811.78 mg/kg, which belongs to WHO Class III of toxic chemicals. However, in-depth toxicity evaluation by the comet assay showed that the four tested species induced significant () DNA damage in PBMCs. γ-Sitosterol was previously reported to possess antihyperglycemic activity by increasing insulin secretion in response to glucose. Nonetheless, consumers should consider its toxicity, and the amount of consumption should be of concern. |
en_US |
dc.description.sponsorship |
This study was financially supported by the Khon Kaen University’s Graduate Research Fund Academic Year 2015 (Grant no. 58132101), Buriram Rajabhat University, and the 2015 TTSF Science & Technology Research Grant by Toray Science Foundation (TSF), Japan. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
มหาวิทยาลัยราชภัฏบุรีรัมย์ |
en_US |
dc.subject |
Phytochemical |
en_US |
dc.subject |
Lagerstroemia Species |
en_US |
dc.title |
Major Phytochemical as γ-Sitosterol Disclosing and Toxicity Testing in Lagerstroemia Species |
en_US |
dc.title.alternative |
Major Phytochemical as γ-Sitosterol Disclosing and Toxicity Testing in Lagerstroemia Species |
en_US |
dc.type |
Research |
en_US |
dc.contributor.emailauthor |
raccha@kku.ac.th |
en_US |
dc.contributor.emailauthor |
prapaparn.sk@bru.ac.th |
en_US |