Abstract E-Commerce supply chain managed today helps support the logistic growth. The indicators used to measure the success of this business type include quantity and circulation which gives higher results when activities relevant to logistic E-Commerce are conducted and applied which help increase the income and export of Thailand for more than 50%. Moreover, the relationship between the factors both internal and external organizations and level of organizational self-evaluation were analyzed to study the internal factors of the organizations that supported the entrepreneurs to achieve success when they applied the business to E-Commerce, and to study the crucial activities emphasized by the organization to apply Alibaba.com in the B2B Small and Medium Enterprises (SMEs). The analysis results carried out by Multiple Regression Analysis revealed that the competitive factors had the relationship with the level of organizational self-evaluation by statistical significance at 0.05 levels. The relationship moved in the same direction which included the internal factors of the organization that helped increase the success based on the strategies, the models used in the E-Commerce system, and strategies used in the E-Commerce system and SMEs. If the competition increases, the organization will adapt itself to bring all product types of SMEs to distribute through the E-Commerce system further.